workvafin
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workvafin [2019/11/18 12:21] krian |
workvafin [2020/04/03 20:18] (current) |
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| **4-** We will evaluate the impact of disrupting variants in each gene **independently** of these gene lists. Each gene list correspond to all the genes that compose a single circuit from related and non related pathways to the disease, circuits are named after their effector node: | **4-** We will evaluate the impact of disrupting variants in each gene **independently** of these gene lists. Each gene list correspond to all the genes that compose a single circuit from related and non related pathways to the disease, circuits are named after their effector node: | ||
| - | * {{ :listagenesKO_diabetesRap1.txt | Example 1: Rap1 signaling pathway: PRKCI PARD6A PARD3}} | + | * {{ :listagenesKO_diabetesRap1.txt | Gene list for example 1: Rap1 signaling pathway: PRKCI PARD6A PARD3}} |
| - | * {{ :listagenesKO_diabetesChemokine.txt | Example 2: Chemokynes signaling pathway: PARD3-PRKCZ-TIAM1}} | + | * {{ :listagenesKO_diabetesChemokine.txt | Gene list for example 2: Chemokynes signaling pathway: PARD3-PRKCZ-TIAM1}} |
| - | * {{ :listagenesKO_diabetesTNF.txt | Example 3: TNF signaling pathway:CREB3}} | + | * {{ :listagenesKO_diabetesTNF.txt | Gene list for example 3: TNF signaling pathway:CREB3}} |
| - | After choosing one or more from the studied example and prepare a list of gene(s) in txt format as described [[gene_list_file_format|her]]. We need to upload it the same way we did to upload expression data. Both gene names and entrez ids are accepted. Select Gene list as data type. | + | After choosing one or more from the studied example and prepare a list of gene(s) in txt format as described [[gene_list_file_format|here]]. We need to upload it the same way we did to upload expression data. Both gene names and entrez ids are accepted. Select Gene list as data type. |
| **5-** Press the //Variant Interpreter// button. | **5-** Press the //Variant Interpreter// button. | ||
workvafin.1574079662.txt.gz · Last modified: 2020/04/03 20:17 (external edit)
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