CoV-HiPathia

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
====== Worked example : Perturbation effect ======
  * Log in Hipathia using login button on the top right corner, the login panel will appear. you can also login using an anonymous user. Please visit [[logging_in|Logging in]] in to further information on this step. 
{{ :loginhipathia.png |}}
  * By clicking the Perturbation effect tool in the menu, the empty form will appear.
{{ :formeexampleperturbationeffect.png |}}
  * Press the run example button, A study will appear on the My studies panel and will be processed.
{{ :run_example.png |}}
  * Once finished, click on it to open the view window.
{{ :finishedexampleperturbationeffect.png |}}
  * The view window will appear.
{{ :perturbationeffectexample1.png |}}
  * Select the genes whose you want to modify its expression value. You can either click on a gene on the pathway viewer and change its value.
{{ :perturbationeffectexamplechangevalue1.png |}}
or search it in the Search genes… box of the Add genes panel. 
{{ :drug.mp4?900 |}}
  *  You can modify the expression level of the genes listed in the Add genes panel and remove them from the list by pressing the **X** button to their right. The expression level of the removed genes will return to their original value.

For this example we fix the following expression values: 
     * IL6
{{ :addgenesexample.png |}}

  * Select the drugs targeting the objective genes if desired. We selected the "Siltuximab" drug for this example.
  * Press the Update button from the Gene list panel.{{ :updatebtn.png |}}
The comparison is performed and the results prepared. 
{{ :loadingperturbationeffectstudy.png |}}
  * Visualize the results. For further information in the interpretation of the results, see [[Perturbation effect results|Perturbation effect results]].
CoV-HiPathia

User Tools

Site Tools

Page Tools
