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--- worked_example_perturbation_effect [2021/01/26 16:11] – mpena
+++ worked_example_perturbation_effect [2024/02/27 13:31] (current) – [References] krian
@@ Line 84: / Line 84: @@
   * The PLA2G4B circuit. //PLA2G4B// is highly expressed in the pancreas and this gene has been described to modulate the sensitivity of pancreatic cancer cells to chemoradiation treatment [6].
-Among the most represented effector genes affected by the knock-down simulation, we want to highlight the roles of //PLA2G4B//, //MAPK1//, //CDKN1A//, //ELK1//, //PRKCA//, and //CAMK2A// in processes such as signal transduction, calcium metabolism, and cell cycle regulation. These mechanisms have been highly related to cell proliferation and cancer progression, therefore inactivating the circuits that trigger these effectors would result in a potential reduction of cancer prognosis, consistent with the results observed in //Blasco et al.// [1].
+Among the most represented effector genes affected by the knock-down simulation, we want to highlight the roles of //PLA2G4B//, //MAPK1//, //CDKN1A//, //ELK1//, //PRKCA//, and //CAMK2A// in processes such as signal transduction, calcium metabolism, and cell cycle regulation. These mechanisms have been highly related to cell proliferation and cancer progression, therefore inactivating the circuits that trigger these effectors would result in a potential reduction in cancer progression, which is consistent with the results observed in //Blasco et al.// [1].
 ==== References ====
@@ Line 100: / Line 100: @@
 [6]    D. Wei et al., “Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair,” Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res., vol. 19, no. 16, pp. 4422–4432, Aug. 2013, doi: 10.1158/1078-0432.CCR-13-0788.
+/* Visualize the results. For further information in the interpretation of the results, see [[Perturbation effect results|Perturbation effect results]].*/
-  /* Visualize the results. For further information in the interpretation of the results, see [[Perturbation effect results|Perturbation effect results]].*/