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worked_example_perturbation_effect [2019/08/08 16:02] krian |
worked_example_perturbation_effect [2020/10/16 16:02] (current) krian |
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* Once finished, click on it to open the view window. | * Once finished, click on it to open the view window. | ||
{{ :finishedexampleperturbationeffect.png |}} | {{ :finishedexampleperturbationeffect.png |}} | ||
- | * | + | * The view window will appear. |
+ | {{ :perturbationeffectexample1.png |}} | ||
+ | * Select the genes whose you want to modify its expression value. You can either click on a gene on the pathway viewer and change its value. | ||
+ | {{ :perturbationeffectexamplechangevalue1.png |}} | ||
+ | or search it in the Search genes… box of the Add genes panel. | ||
+ | {{ :drug.mp4?900 |}} | ||
+ | * You can modify the expression level of the genes listed in the Add genes panel and remove them from the list by pressing the **X** button to their right. The expression level of the removed genes will return to their original value. | ||
+ | |||
+ | For this example we fix the following expression values: | ||
+ | * IL6 | ||
+ | {{ :addgenesexample.png |}} | ||
+ | |||
+ | * Select the drugs targeting the objective genes if desired. We selected the "Siltuximab" drug for this example. | ||
+ | * Press the Update button from the Gene list panel.{{ :updatebtn.png |}} | ||
+ | The comparison is performed and the results prepared. | ||
+ | {{ :loadingperturbationeffectstudy.png |}} | ||
+ | * Visualize the results. For further information in the interpretation of the results, see [[Perturbation effect results|Perturbation effect results]]. |