worked_example_perturbation_effect
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worked_example_perturbation_effect [2019/08/08 16:36] krian |
worked_example_perturbation_effect [2020/10/16 16:02] (current) krian |
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| {{ :perturbationeffectexamplechangevalue1.png |}} | {{ :perturbationeffectexamplechangevalue1.png |}} | ||
| or search it in the Search genes… box of the Add genes panel. | or search it in the Search genes… box of the Add genes panel. | ||
| - | {{ :searchgene.png |}} | + | {{ :drug.mp4?900 |}} |
| * You can modify the expression level of the genes listed in the Add genes panel and remove them from the list by pressing the **X** button to their right. The expression level of the removed genes will return to their original value. | * You can modify the expression level of the genes listed in the Add genes panel and remove them from the list by pressing the **X** button to their right. The expression level of the removed genes will return to their original value. | ||
| For this example we fix the following expression values: | For this example we fix the following expression values: | ||
| - | * CTNND1 | + | * IL6 |
| - | * RHOA | + | |
| - | * TCF7 | + | |
| {{ :addgenesexample.png |}} | {{ :addgenesexample.png |}} | ||
| + | |||
| + | * Select the drugs targeting the objective genes if desired. We selected the "Siltuximab" drug for this example. | ||
| + | * Press the Update button from the Gene list panel.{{ :updatebtn.png |}} | ||
| + | The comparison is performed and the results prepared. | ||
| + | {{ :loadingperturbationeffectstudy.png |}} | ||
| + | * Visualize the results. For further information in the interpretation of the results, see [[Perturbation effect results|Perturbation effect results]]. | ||
worked_example_perturbation_effect.1565282168.txt.gz · Last modified: 2020/04/03 20:17 (external edit)
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