Differences

This shows you the differences between two versions of the page.

--- start [2016/02/24 14:54] – mhidalgo
+++ start [2024/03/08 12:10] (current) – krian
@@ Line 1: / Line 1: @@
 ====== Welcome to HiPathia! ======
-HiPathia is a web tool for the interpretation of the consequences of the combined changes of gene expression levels and/or genomic mutations in the context of signalling pathways. hiPathia transforms uninformative gene expression and/or genomic variation data into signaling circuit activities, which carry information on the different cell functionalities triggered by them. Such signalling activities not only account for the underlying molecular mechanisms of diseases or the mode of action of drugs but they can also be used as mechanistic features for the prediction of complex phenotypes.
+HiPathia is a web tool for the interpretation of the consequences of the combined changes of gene expression levels and/or genomic mutations in the context of signalling pathways.
+HiPathia transforms uninformative gene expression and/or genomic variation data into signaling circuit activities, which carry information on the different cell functionalities triggered by them. Such signaling activities not only account for the underlying molecular mechanisms of diseases or the mode of action of drugs but they can also be used to interpret the effect of mutations or gene expression perturbations.
 Along this tutorial you will learn how to use the HiPathia pathway suite and find different worked examples.
-  * [[What can do HiPathia for you|What can do HiPathia for you]]
+{{ :home.png?direct |http://hipathia.babelomics.org/}}
-  * How to use HiPathia:
+The HiPathia web server integrates four different pathway analysis modules:
-    * [[Logging in|Logging in]]
+  * **[[differential_signaling|Differential signaling]]** provides an estimation of significant cell signaling activity changes across different conditions.
-    * [[General overview|General overview]]
+  * **[[Prediction|Prediction]]** allows you to train a prediction test and test it with different data.
-    * [[Workflow|Workflow]]
+  * **[[Perturbation effect|Perturbation effect]]**  is an interactive working environment to simulate the effect of different interventions (e.g. knock-out, over-expression, drugs, etc.) over the activity of signaling circuits in the pathways, as well as their potential functional consequences in the cell.
-    * [[Upload your data|Upload your data]]
+  * **[[vafin|Variant interpreter]]**  provides an estimation on the potential impact of genomic variation on cell signaling and ultimately on cell functionality.
-  * Tools:
-    * [[Differential signaling|Differential signaling]]
-    * [[Prediction|Prediction]]
-  * Worked examples:
-    * [[Worked example Differential example|Worked example Differential signaling]]
-    * [[Worked example Prediction - Train|Worked example Prediction - Train]]
-    * [[Worked example Prediction|Worked example Prediction - Test]]
-  * For further learning:
-    * [[Differential signaling exercises|Differential signaling exercises]]