Please, use the following convention to cite Hipathia tool: Kinza Rian, Marta R. Hidalgo, Cankut Çubuk, Matias M. Falco, Carlos Loucera, Marina Esteban-Medina, Inmaculada Alamo-Alvarez, María Peña-Chilet, Joaquín Dopazo, Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data, Computational and Structural Biotechnology Journal,Volume 19, 2021, Pages 2968-2978, ISSN 2001-0370, https://doi.org/10.1016/j.csbj.2021.05.022. Article : PDF (3.6M)

Hidalgo, M. R., Cubuk, C., Amadoz, A., Salavert, F., Carbonell-Caballero, J., & Dopazo, J. (2017). High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes. Oncotarget, 8(3), 5160–5178. http://doi.org/10.18632/oncotarget.14107

Article : PDF (3.6M)

If you use the Variant Interpreter option, please, use this instead:

Peña-Chilet M, Esteban-Medina M, Falco MM, Rian K, Hidalgo MR, Loucera C, Dopazo J.(2019) Using mechanistic models for the clinical interpretation of complex genomic variation. Sci Rep. 9(1):18937. http://doi.org/10.1038/s41598-019-55454-7.

Related papers:

• Esteban-Medina, M., Peña-Chilet, M., Loucera, C. et al. Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models. BMC Bioinformatics 20, 370 (2019). https://doi.org/10.1186/s12859-019-2969-0
• Loucera, C., Esteban-Medina, M., Rian, K. et al. Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection. Sig Transduct Target Ther 5, 290 (2020). https://doi.org/10.1038/s41392-020-00417-y