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function_based_analysis

Function based analysis

For each of the functional analysis selected to be performed, the same descriptive statistics as in the Path values case are shown:

  • GO terms/Uniprot keywords values: You can download the matrix of function values by clicking on GO terms values or Uniprot keywords values.
  • Heatmap: A heatmap is a graphical representation of the values of a matrix. A not-supervised clustering is performed on the data per columns (samples). A good separation between the two colors of the upper bar of the heatmap indicates that the differences between the two groups are big enough to discriminate between them.
  • PCA: A Principal Components Analysis is performed in order to see if the matrix contains information enough to separate between the two groups.
  • GO terms/Uniprot keywords significance: Ordered table of the functions significance. More significant terms are displayed in the upper part of the table. For each functional term, the following information is shown:
    • path/term: Name of the function.
    • UP/DOWN: Up when the function is up-regulated in the disease case, DOWN otherwise.
    • statistic: Statistic of the of the statistic test.
    • p.value: P-value of the statistic test.
    • FDRp.value: Adjusted p-value of the statistic test using the FDR method.
    • Fold Change
    • logFC
function_based_analysis.txt · Last modified: 2019/08/05 22:11 by krian